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NCF4 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA529000

Catalog No. PIPA529000


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Description

Description

PA5-29000 targets NCF4 in WB applications and shows reactivity with Human samples. The PA5-29000 immunogen is recombit protein fragment corresponding to a region within amino acids 1 and 298 of Human NCF4. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Specifications

Specifications

NCF4
Polyclonal
Unconjugated
NCF4
Liquid
NCF4
Recombit protein fragment corresponding to a region within amino acids 1 and 298 of Human NCF4
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
0.87 mg/mL
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Q15080
NCF, P40PHOX, SH3PXD4, NCF-4, SH3 and PX domain-containing protein 4, neutrophil NADPH oxidase factor 4, neutrophil cytosol factor 4, p40-phox
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
4689
Documents
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