NCF4 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA529000
PA5-29000 targets NCF4 in WB applications and shows reactivity with Human samples. The PA5-29000 immunogen is recombit protein fragment corresponding to a region within amino acids 1 and 298 of Human NCF4. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
|Recombit protein fragment corresponding to a region within amino acids 1 and 298 of Human NCF4|
|Antigen affinity chromatography|
|0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7|
|NCF, P40PHOX, SH3PXD4, NCF-4, SH3 and PX domain-containing protein 4, neutrophil NADPH oxidase factor 4, neutrophil cytosol factor 4, p40-phox|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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