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NEDD4 Rabbit anti-Equine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523462

Catalog No. PIPA523462


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Description

Description

The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.
Specifications

Specifications

NEDD4
Polyclonal
Unconjugated
NEDD4
Liquid
NEDD4
Synthetic peptide (222 RPYTFKDFVLHPRSHKSR 239) of NEDD4 protein.
Protein A
RUO
Antibody
Polyclonal
Equine, Human, Mouse, Non-human primate, Rat
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
P46934, P46935, Q62940
PIG53, NEDD4-1, RPF1, E3 ubiquitin-protein ligase NEDD4, NEDD-4, cell proliferation-inducing gene 53 protein, neural precursor cell expressed developmentally down-regulated protein 4, receptor-potentiating factor 1
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
100054735, 17999, 25489, 4734
Documents
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