NEDD4 Rabbit anti-Equine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523492
DescriptionThe E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. NEDD4 contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. NEDD4 acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence, NEDD4 acts as down regulator of Notch-1 gene expression.
|Synthetic peptide (950 DKLQMAIENTQGFDGVD 1000) of NEDD4 protein.|
|Antigen affinity chromatography|
|Equine, Human, Mouse, Non-human primate, Rat|
|PBS with 0.05% BSA and 0.05% sodium azide|
|P46934, P46935, Q62940|
|PIG53, NEDD4-1, RPF1, E3 ubiquitin-protein ligase NEDD4, NEDD-4, cell proliferation-inducing gene 53 protein, neural precursor cell expressed developmentally down-regulated protein 4, receptor-potentiating factor 1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|100054735, 17999, 25489, 4734|
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