Nephrin Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520330
Despite its predicted molecular weight, Nephrin often migrates at a lower molecular weight in SDS-PAGE. A suggested positive control is mouse kidney tissue lysate. PA5-20330 can be used with blocking peptide PEP-0450.Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth. Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm.
|A 14 amino acid peptide from near the carboxy terminus of human Nephrin.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|O60500, Q9QZS7, Q9R044|
|CNF, NPHN, nephrin; nephrin; renal glomerulus-specific cell adhesion receptor|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|4868, 54631, 64563|
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