NGF Rabbit anti-Avian, Human, Mouse, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA118377
PA1-18377 detects beta NGF from human, mouse, rat, and avian samples. This antibody does not react with bovine protein. A cross reactivity of less than 1% to recombit human BDNF, NT3, NT4/5 by ELISA has been shown. PA1-18377 has been successfully used in immunohistochemistry, ELISA, Western blot, and inhibition assay procedures. The PA1-18377 immunogen is native mouse beta NGF purified from submaxillary salivary gland. Reconstitute with 500 µL of distilled water. Glycerol (1:1) may be added for additional stability.Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons. Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.
|Antibody with no preservative|
|P01138, P01139, P25427|
|beta Nerve Growth Factor|
|-20° C, Avoid Freeze/Thaw Cycles|
|18049, 310738, 4803|
|ELISA, Immunohistochemistry, Inhibition Assays, Western Blot|
|Native mouse beta NGF purified from submaxillary salivary gland.|
|Avian, Human, Mouse, Rat|
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