Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

NGF Chicken anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Chicken Polyclonal Antibody

Manufacturer:  Invitrogen PA19516

Catalog No. 01-674-399


Add to cart

Description

Description

PA1-9516 detects Nerve growth factor in human, mouse and rat samples. PA1-9516 has been successfully used in Western blot, Immunohistochemistry and ELISA procedures. The PA1-9516 immunogen is a synthetic peptides corresponding to residues 74-85 & 113-124 of mouse NGF protein.

Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons. Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.
Specifications

Specifications

NGF
Polyclonal
Unconjugated
NGF
Liquid
NGF
Synthetic peptides corresponding to residues 74-85 & 113-124 of mouse NGF protein.
IgY fraction
RUO
Antibody
Polyclonal
Human, Mouse, Rat
ELISA, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P01138, P01139, P25427
Beta-NGF
Chicken
IgY
500 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
18049, 310738, 4803
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit