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Nesprin 1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA15839

Catalog No. 01-674-982


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Description

Description

PA1-5839 detects Nesprin 1 in human samples. PA1-5839 has been successfully used in Western blot, ICC/IF and immunohistochemistry (frozen) procedures. The PA1-5839 immunogen is a synthetic peptide, conjugated to KLH, corresponding to residues GRSTPNRQKTPRGKC.

There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as  ft.dystrophins of the nucleus ft. to maintain nuclear organization and structura integrity
Specifications

Specifications

Nesprin 1
Polyclonal
PBS with 0.025% sodium azide
Q8NF91
RP1-130E4.2, 8B, ARCA1, C6orf98, CPG2, DKFZp781J13156, EDMD4, FLJ30878, FLJ41140, KIAA0796, KIAA1262, KIAA1756, MYNE1, SCAR8, dJ45H2.2
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
23345
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
Unconjugated
SYNE1
Liquid
SYNE1
Synthetic polypeptide GRSTPNRQKTPRGKC residues 3212-3226) conjugated to KLH
Affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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