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NTN1 Rabbit anti-Bovine, Feline, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112869

Catalog No. 01-675-849


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Description

Description

A suggested positive control for this product is MDCKII cell lysate.

Netrin 1’s main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.
Specifications

Specifications

NTN1
Polyclonal
Unconjugated
NTN1
Liquid
NTN1
Synthetic peptide corresponding to human Netrin 1.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Bovine, Feline, Human, Mouse, Non-human primate, Rat
Western Blot
1 mg/mL
PBS with 0.08% sodium azide
O95631, O09118, Q924Z9
NTN1L
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
101082606, 114523, 18208, 522767, 9423
Documents
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