NTN1 Rabbit anti-Bovine, Feline, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112869
A suggested positive control for this product is MDCKII cell lysate.Netrin 1’s main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.
|Synthetic peptide corresponding to human Netrin 1.|
|Ammonium sulfate precipitation|
|Bovine, Feline, Human, Mouse, Non-human primate, Rat|
|PBS with 0.08% sodium azide|
|O95631, O09118, Q924Z9|
|-20° C, Avoid Freeze/Thaw Cycles|
|101082606, 114523, 18208, 522767, 9423|
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