anti-Netrin 1 Polyclonal, Thermo Scientific™

Netrin 1 Polyclonal Ab PA1-12869 from Thermo Scientific™ specifically detects Netrin 1 in Bv, Feline, Hu, Ms, Nhp and Rt samples, and it is validated for WB

Manufacturer: Invitrogen PA112869

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Catalog No. 01-675-849

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    Specifications

    Antigen Netrin 1
    Applications Western Blotting
    Conjugate Unlabeled
    Cross Reactivity Bovine,Feline,Human,Mouse,Non-human primate,Rat
    Format Purified
    Formulation 100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
    Gene Accession No. O09118, O95631, Q924Z9
    Gene Alias NTN1L
    Gene Symbols NTN1
    Host Species Rabbit
    Immunogen Synthetic peptide corresponding to human Netrin 1.
    Isotype IgG
    Quantity 100μg
    Species Reactivity Bovine, Feline, Human, Mouse, Non-human primate, Rat
    Storage Requirements Avoid Freeze/Thaw Cycles
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal
    Gene ID (Entrez) 101082606, 114523, 18208, 522767, 9423

    Netrin 1 Polyclonal Ab PA1-12869 from Thermo Scientific™ specifically detects Netrin 1 in Bv, Feline, Hu, Ms, Nhp and Rt samples, and it is validated for WB

    Netrin 1’s main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.
    Host Species: Rabbit
    Cross Reactivity: Bovine, Feline, Human, Mouse, Non-human primate, Rat
    Isotype: IgG
    Immunogen: Synthetic peptide corresponding to human Netrin 1.
    Formulation: 100µg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
    Synonyms: NTN1L
    Uniprot Accession: O09118, O95631, Q924Z9
    Entrez GeneID: 101082606, 114523, 18208, 522767, 9423
    Gene Symbol: NTN1
    A suggested positive control for this product is MDCKII cell lysate.

  • Description & Specifications

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