NRG1 Mouse anti-Human, Clone: 147705, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523776
This antibody recognizes an epitope found in the EGF-like domain of NRG1- beta 1 (amino acids 179-246). This antibody detects Recombinant human SMDF (Sensory and Motor neuron-Derived Factor), but it does not recognize the EGF-like domain of human NRG1-alpha (amino acids 177-241). The epitope is present within amino acids 213-230 of human NRG1-beta 1. This segment is present in all NRG1 beta isoforms, GGF-2 (glial growth factor), and SMDF, but it is absent from NRG1-alpha, NDF43, and NRG1-gamma. Reconstitute at 0.5 mg/mL in sterile PBS.The neuregulins are a family of ErbB/HER ligands encoded by four genes. Neuregulin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregulin-1 includes a range of isoforms with varying glycosylation, regulation of expression and function. Neuregulin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregulin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregulin-1 has been linked to schizophrenia and has diverse neural functions. Neuregulin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions.
|PBS with 5% trehalose and No Preservative|
|Pro-neuregulin-1, membrane-bound isoform, Pro-NRG1, NRG1, GGF, HGL, HRGA, NDF, SMDF|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Western Blot|
|E. coli-derived recombit human NRG1-beta 1/HRG1-beta 1 Ser2-Lys246|
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