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NRG1 Mouse anti-Human, Clone: 147705, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523776

Catalog No. PIMA523776


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Description

Description

This antibody recognizes an epitope found in the EGF-like domain of NRG1- beta 1 (amino acids 179-246). This antibody detects Recombinant human SMDF (Sensory and Motor neuron-Derived Factor), but it does not recognize the EGF-like domain of human NRG1-alpha (amino acids 177-241). The epitope is present within amino acids 213-230 of human NRG1-beta 1. This segment is present in all NRG1 beta isoforms, GGF-2 (glial growth factor), and SMDF, but it is absent from NRG1-alpha, NDF43, and NRG1-gamma. Reconstitute at 0.5 mg/mL in sterile PBS.

The neuregulins are a family of ErbB/HER ligands encoded by four genes. Neuregulin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregulin-1 includes a range of isoforms with varying glycosylation, regulation of expression and function. Neuregulin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregulin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregulin-1 has been linked to schizophrenia and has diverse neural functions. Neuregulin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions.
Specifications

Specifications

NRG1
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q02297
Pro-neuregulin-1, membrane-bound isoform, Pro-NRG1, NRG1, GGF, HGL, HRGA, NDF, SMDF
Mouse
IgG1
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3084
ELISA, Western Blot
147705
Unconjugated
NRG1
Lyophilized
NRG1
E. coli-derived recombit human NRG1-beta 1/HRG1-beta 1 Ser2-Lys246
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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