NF1 Mouse anti-Human, Mouse, Rat, Clone: McNFn27b, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA1085
Neurofibromin is a member of the GTPase-activating (GAP) class of proteins. These proteins enhance the GTPase activity of signaling G-Proteins like Ras. The NF1 gene is also classified as a tumor suppressor gene, and many studies have shown that mutations at the NF1 locus produce neurofibromas, rhabdomyosarcomas, leimyosarcomas, mental retardation and memory deficiency. Neurofibromin has also been associated with the intermediated filaments of the cytoskeleton. NF1 is expressed at its highest levels during periods of desmosome formation and mutations of NF1 produce variable cell sizes and morphologies.MA1-085 detects neurofibromin in human, rat, and mouse cells.MA1-085 has been successfully used in Western blot, and immunohistochemistry procedures. By Western blot, this antibody detects a ~240-260kDa protein. The MA1-085 immunogen is a synthetic peptide corresponding to the N-terminal residues 27-41 of human neurofibromin.
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|P21359, Q04690, P97526|
|NF1, WSS, NFNS, VRNF|
|-20° C, Avoid Freeze/Thaw Cycles|
|18015, 24592, 4763|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|Synthetic peptide corresponding to the N-terminal residues 27-41 of human neurofibromin.|
|Human, Mouse, Rat|
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