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NF-H Mouse anti-Mammalia, Clone: NF-01, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119172

Catalog No. 01-675-942


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Description

Description

This antibody recognizes a phosphorylated epitope on heavy neurofilament protein (210 kDa) of various species.

Neurofilaments (NFs) are a type of intermediate filament (IF) expressed almost exclusively in neuronal cells, and in those cells most prominently in large axons. NFs in most vertebrates are composed of three different polypeptide chains with different molecular weights - neurofilament heavy protein (NF-H), medium (NF-M) and light protein (NF-L), which share sequence and structural similarity in a coiled-coil core domain, but differ in the length and sequence of their N-termini and more dramatically of their C-termini which in the case of NF-M and NF-H form the flexible extensions that link NFs to each other and to other elements in the cytoplasm. The protein segment on the C-terminal side of the human NF-H rod is uniquely long (more than 600 amino acids) compared to other IF proteins and is highly charged (> 24 % Glu, > 25 % Lys), rich in proline (> 12 %) and improverished in cysteine, methionine and aromatic amino acids. Its most remarkable feature is a repetitive sequence that covers more than half its lenght and includes the sekvence motif Lys-Ser-Pro (KSP) greater than 40 times. Plasma neurofilament heavy chain level has been proposed as a marker of axonal injury and clinical use of its degeneration and loss has been suggested as a biomarker of several neurodegenerative diseases.
Specifications

Specifications

NF-H
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P12036, P19246, P12037, P16884
NFH, NF-H, NHC, 200 kDa neurofilament protein, KIAA0845, Neurofilament heavy polypeptide, Neurofilament triplet H protein
Mouse
IgG1
100 μg
4° C, do not freeze
Primary
100156492, 24587, 380684, 4744
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
NF-01
Unconjugated
NEFH
Liquid
NEFH
Pellet of pig brain cold-stable proteins after depolymerization of microtubules.
Protein A
RUO
Antibody
Monoclonal
Mammalia
Documents
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