NCS1 Rabbit anti-Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1939
The neuronal calcium sensor (NCS) proteins are bind calcium through EF-hand motifs and are predominantly expressed in neurons. Photoreceptor cells express type A sensors and include the proteins recoverin, S-modulin, and visinin. Type B receptors are expressed in neurons and include NCS1 and the Drosophila homolog frequenin, and VILIP. NCS1 has been shown to regulate neurosecretion in a calcium-dependent manner, potentiates nitric oxide synthase activity, and can activate calcineurin and 3'-5' nucleotide phosphodiesterase.PA1-939 detects neuronal calcium sensor-1 (NCS-1) from rat tissues.PA1-939 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~20kDa protein representing NCS-1 from rat brain extract.PA1-939 immunizing peptide corresponds to amino acid residues 161-190 from rat NCS-1. This sequence is completely conserved in mouse, rat, chicken and human NCS-1. There is a single amino acid substitution in this region for Xenopus NCS-1.
|Synthetic Peptide: D(161) G K L T L Q E F Q E G S K A D P S I V Q A L S L Y D G L V(190)|
|Antigen affinity chromatography|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|-20° C, Avoid Freeze/Thaw Cycles|
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