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MilliporeSigma™ anti-Neuropeptide Y, Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC223L100UL

Catalog No. PC223L100UL


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Description

Description

Specifically detects Neuropeptide Y Clone: in Amphibian, Avian, Feline, Fish, Human, Rat samples, and it is validated for Immunohistochemistry (Frozen)

Neurotransmitters can be defined as chemical substances that are released by the presynaptic neuron before being bound by receptors on the postsynaptic cell surface. It has been well established that the nervous system utilizes neurotransmitters for cell signaling. Neurotransmitters can be divided into two groups; low molecular weight transmitter molecules such as biogenic amines, purines, or amino acids, and bioactive peptides, of which more than 50 members have been identified in the mammalian central nervous system. Many low molecular weight neurotransmitters are produced within the axon terminal from common cellular metabolites and packaged into synaptic vesicles. In contrast, neuropeptides are synthesized in the cell body and packaged into large dense core vesicles for delivery to the presynaptic membrane. The transport and delivery of vesicles containing neurotransmitter is a highly regulated and complex process. Neuropeptide Y (NPY) is a 36 amino acid peptide belonging to the pancreatic polypeptide family of neuroendocrine hormones. NPY is abundantly expressed in neurons within the central and peripheral nervous systems, including the hypothalamus and pituitary. NPY is a potent stimulator of food intake, and may also influence other growth hormones. A family of neuropeptide Y receptors (Y1-Y5) have been identified which recognize both neuropeptide Y and the related Peptide YY. The immunolocalization, neuronal distribution, and vesicular compartmentalization of neurotransmitter molecules and their precursors are important for understanding the modulation, regulation, and function of neurotransmitters in the nervous system.
Specifications

Specifications

Neuropeptide Y
Unconjugated
Undiluted Serum
porcine neuropeptide Y
100μL
−20°C
Polyclonal
Amphibian, Avian, Feline, Fish, Human, Rat
Immunohistochemistry (Frozen)
Undiluted serum.
Rabbit
IgG
RUO
Primary
Recognizes neuropeptide Y in cortex, caudate, putamen, and paraventricular nucleus.
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