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Neuropilin-2 Mouse anti-Rat, Unlabeled, Clone: 54, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611262

Catalog No. BDB611262

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

The precise navigation of axons to their targets in the developing nervous system is essential for establishment of neuronal connectivity. This is achieved through the recognition of attractant and repellent signals delivered to neurons by the netrins and semaphorins, which interact with receptors on axons and growth cones. The semaphorins are a large family of secreted and transmembrane glycoproteins that function as chemorepellents of developing neurons. Neuropilin-1 (NP-1) and neuropilin-2 (NP-2) (44% amino acid identity) are receptors
for various members of the secreted semaphorin family. While NP-1 binds to class III semaphorins (Sema III, Sema E, and Sema IV), NP-2 is a high affinity receptor for Sema E and Sema IV, but not Sema III. Although they interact with distinct but overlapping subsets of semaphorins, NP-1 and NP-2 exhibit unique expression patterns during nervous system development. Moreover, NP-1 and NP-2 can form homooligomers which can, in turn, form heterooligomers. Thus, their interactions and differential patterns of expression implicate NP-1 and NP-2 in the coordination of axon guidance during neurodevelopment.

Host Species: Mouse
Clone: 54
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Rat Neuropilin-2 aa.610-721
Formula Weight [Chemical]: 104kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

Neuropilin-2
54
Unconjugated
Murine
IgG1
RUO
Primary
Rat
Western Blot
250μg/mL
Affinity Purified
Rat Neuropilin-2 aa.610-721
50μg
Cell Biology
Monoclonal
Documents
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