Sortilin Polyclonal Antibody, Invitrogen™

Sheep Polyclonal Antibody

Supplier:  Thermo Scientific OSS00052W

Catalog No. PIOSS00052W

Description

Reconstitute with 100 μL of distilled water.

This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.

Specifications

• Antigen: Sortilin
• Classification: Polyclonal
• Formulation: whole serum with no preservative
• Gene Accession No.: Q6PHU5, O54861
• Gene Symbols: SORT1
• Immunogen: A synthetic peptide from the extracellular, N-terminal part of rat Sortilin
• Regulatory Status: RUO
• Gene ID (Entrez): 20661, 83576
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Gene: Sort1
• Gene Alias: Neurotensin receptor 3, NTR3, Glycoprotein 110, Gp110, Nt3, Nts3
• Host Species: Sheep
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG