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Ly-6G/Ly-6C Rat anti-Mouse, Clone: NIMP-R14, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA140038

Catalog No. 01-676-494


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Description

Description

This clone is highly specific for murine Ly-6G and Ly-6C. It has been successfully used to stain polymorphonuclear (PMN) cells and monocytes for fluorescent activated cell sorting and in frozen and paraffin sections. Treatment with this antibody in vivo leads to neutropenia and has inhibitory effect on local immune responses. Furthermore, it has been shown to be useful for depletion of neutrophils in mice. It depletes neutrophils as soon as 6 hours after injection and up to 6 days. Suggested negative control: mouse thymocytes.

The Ly-6G/-6C locus encodes a family of Ly-6 proteins including Ly-6G and Ly-6C. Ly-6 antigens have a molecular weight between 15,000 and 18,000. Ly6G is together with Ly6c a component of the myeloid differentiation antigen Gr-1. Ly6G a GPI-anchored protein and is a good marker of peripheral neutrophils. Although predomitly presents on neutrophils, it is also expressed on a subset of eosinophils, differentiating pre-monocytes and plasmacytoid dendritic cells. Ly6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon gamma, and may play a role in the development and maturation of lymphocytes. It is expressed on bone marrow cells, monocytes/macrophages, neutrophils, endothelial cells, and T cell subsets. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. However, the physiological role of Ly6G alone remains still unclear.
Specifications

Specifications

Ly-6G/Ly-6C
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and no preservative
P0CW02, P0CW03, P35461
Ly6c1, Ly6c2, Ly6g
Purified BALB/c mouse neutrophils.
Purified
RUO
Antibody
Monoclonal
Mouse
ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
NIMP-R14
Unconjugated
Ly6c2
Liquid
Rat
IgG2b
100 μg
4° C
Primary
100041546, 17067, 546644
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