NFkB p52 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527340
PA5-27340 targets NFkB p100/p52 in Western blot and immunoprecipitation applications and shows reactivity with Human and mouse samples. The PA5-27340 immunogen is recombit protein fragment corresponding to a region within amino acids 658 and 885 of Human NFkB p100/p52. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. For reviews, see Chen et al. (1999) [PubMed 9895331] and Baldwin (1996) [PubMed 8717528].
|Recombit protein fragment corresponding to a region within amino acids 658 and 885 of Human NFkB p100/p52|
|Antigen affinity chromatography|
|Immunoprecipitation, Western Blot|
|PBS with 20% glycerol and 0.01% thimerosal; pH 7|
|H2TF1; LYT-10; LYT10; p52; DNA-binding factor KBF2; lymphocyte translocation chromosome 10 protein; nuclear factor NF-kappa-B p100 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 2; oncogene Lyt-10; nf?b|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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