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NFkB p50 Mouse anti-Human, Clone: 2J10D7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141314

Catalog No. 01-676-612


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Description

Description

This antibody is predicted to react with mouse and rat samples based on sequence homology. Suggested positive control: antigen standard for NFKB1 (transient overexpression lysate), Hela whole cell extract, HeLa cell lysate.

NFkB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products. NFkB is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation. NFKB1 (p50) is a 50KDa functional sub-unit of NF-kB and a member of Rel protein family which is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NFkB factor. Further, NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-binding. The NFkB complex is expressed in most cell types, and is primarily found in the cytoplasm in an inactive state in association with I-kappa-B. Phosphorylation of I-kappa-B releases the complex, allowing translocation to the nucleus and modification of gene expression. Phosphorylation of the p50 subunit at the Ser-337 residue has been shown to significantly increase DNA binding efficiency of the NFkB protein complex. The pathological role of NFkB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.
Specifications

Specifications

NFkB p50
Monoclonal
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
P19838
p50p50; nf?b
Mouse
IgG1, kappa
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
4790
Immunohistochemistry (Paraffin), Western Blot
2J10D7
Unconjugated
NFKB1
Liquid
NFKB1
Human NF-kB (p50).
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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