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NHE-1 (Na+/H+ Exchangers) Mouse, Unlabeled, Clone: 54, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611775

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Catalog No. BDB611775


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Description

Description

The extrusion of H+ in exchange for extracellular Na+ is important for many cellular processes, such as pH homeostasis, volume regulation, and transepithelial ion and water transport. Na+/H+ Exchangers (NHE) are integral membrane proteins that mediate electroneutral exchange of one Na+ ion for one H+ ion. Six NHE forms, NHE-1 thru -6, have been identified. NHE-1 and NHE-6 are widely expressed, while the other NHE forms have restricted expression. The common structure of all NHE forms includes 10-12 N-terminal membrane (M) spanning regions, a conserved M6 and M7 region that may participate in ion transport, and a large C-terminal cytoplasmic region that may be involved in the regulation of ion exchange activity. NHE-1, for example, contains 12 M regions plus domains for volume sensitivity, calmodulin-binding, CHP-binding, and PKC phosphorylation in the cytoplasmic region. Regulation of NHE-1 ion exchange activity may occur through phosphoinositide binding, as well as PKC- and PKA-dependent signaling pathways. Mutation of NHE-1 in mice causes neuronal death in the cerebellum and brainstem, leading to ataxia and seizures. Thus, NHE-1 is a ubiquitous NHE that is essential for normal brain function.

Although this antibody was developed against the NHE-1 antigen, investigators should note that crossreactivity to other NHE isoforms or variants may be possible.

Although this antibody was developed against the NHE-1 antigen, investigators should note that crossreactivity to other NHE isoforms or variants may be possible.

Specifications

Specifications

NHE-1 (Na+/H+ Exchangers)
54
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Na+/H+ Exchangers
Affinity Purified
Rat NHE-1 aa. 682-801
150μg
Cell Biology
Primary
Canine, Human, Murine, Rat
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