Nip1 Mouse, Unlabeled, Clone: 5, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611096
Apoptosis, a selective process of genetically programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. In addition, apoptotic programs in virus-infected cells regulate viral replication and pathogenesis. However, viruses, such as human adenovirus, have evolved methods of circumventing these programs. The adenovirus E1B region encodes a 19kDa protein (19K) that, similar to Bcl-2, suppresses apoptosis via interactions with intracellular proteins such as Bcl-2 family members. In addition, 19K and Bcl-2 interact with members of a novel subfamily of pro-apoptotic proteins which includes Nip1-3 and Nix. These proteins contain C-terminal transmembrane (TM) domains, such as those found in Bcl-2 proteins. The TM domain is important for targeting of proteins to mitochondria and nuclear envelope/ER regions of the cell. More specifically, Nip1 localizes at the nuclear envelope/ER, while Nip3 localizes in mitochondria and other cytoplasmic membrane structures. In addition, Nip1 shares homology with the catalytic domain of mammalian calcium/calmodulin-dependent cyclic nucleotide phosphodiesterases (PDEs) and may have a PDE-like activity.
Immunofluorescence, Western Blotting
|Immunofluorescence, Western Blot|
|Human Nip1 aa. 52-174|
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