MilliporeSigma anti-Nitrotyrosine Rabbit Monoclonal,
Rabbit Monoclonal Antibody
Manufacturer: MilliporeSigma 06284AF488
Specifically detects Nitrotyrosine Clone: in Human samples, and it is validated for ImmunocytochemistryNitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species. Proteins are often targets of reactive species and detection of oxidatively modified proteins is often used as an index of oxidative stress. Peroxynitrite is a strong oxidant formed by reaction of nitric oxide with superoxide. The reaction of proteins with peroxynitrite results in the oxidation of tryptophan and cysteine, as well as the nitration of tyrosine, formation of dityrosine, 2,4 dinitrophenylhydrazine-reactive carbonyls, and protein fragmentation. The formation of 3-nitrotyrosine represents a specific peroxynitrite-mediated protein modification that is different from modifications mediated by reactive oxygen species. Studies show that elevated nitrotyrosine levels are associated with inflammatory conditions, such as atherosclerotic plaques and rheumatoid arthritis.
|Alexa Fluor 488|
|2°C to 8°C for one year from date of shipment|
|Purified rabbit antibody conjugate in PBS with 15 mg/ml BSA and 0.1% sodium azide.|
|Recognizes proteins which are nitrated.|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok
For Research Use Only