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Nitrotyrosine Rabbit anti-Chemical, Polyclonal, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen A21285

Catalog No. A21285


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Description

Description

Nitrotyrosine is a relatively stable product formed from various reaction pathways. Perhaps most notable is the reaction of peroxynitrite (formed from superoxide and nitric oxide (NO) radicals) with tyrosine. As a strong oxidant and nitrating agent, peroxynitrite mediates tyrosine nitration reactions on proteins resulting in inactivation of certain housekeeping enzymes (e. g., alpha1-antiproteinase) as well as endogenous antioxidant enzymes such as catalase and superoxide dismutase (SOD). Nitrotyrosine has been identified as an indicator of cell damage and inflammation, as well as of the production of NO. It is believed that measuring the concentration of nitrotyrosine will serve as a marker for damage caused by NO in the cell. Nitrotyrosine has been implicated in the pathogenesis of several inflammatory, infectious, and degenerative human diseases, such as Alzheimer ft.s and Parkinson ft.s disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), asthma, atherosclerosis, and a variety of conditions precipitated by endothelial injury. At the protein level, tyrosine nitration can lead to loss or alteration of protein function, as demonstrated for the oncogenic protein p53 and the mitochondrial protein, manganese-dependent superoxide dismutase (MnSOD).

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Specifications

Specifications

Nitrotyrosine
Polyclonal
Unconjugated
Liquid
Rabbit
IgG
500 μL
4° C
Primary
Chemical
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 5mM sodium azide; pH 7.2
Nitro-tyrosine
Keyhole limpet hemocyanin (KLH) containing nitrated tyrosines
Purified
RUO
Antibody
Polyclonal
Documents
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