Nkx2.5 Mouse anti-Human, Clone: 4B11, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA518671
Peptide Sequence: MFPSPALTPT PFSVKDILNL EQQQRSLAAA GELSARLEAT LAPSSCMLAA FKPEAYAGPE AAAPGLPELR AELGRAPSPA KCASAFPAAP AFYPRAYSDP DPAKDPRAEK KELCALQKAV ELEKTEADNA *Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation, as well as determining the temporal and spatial patterns of development (Shiojima et al., 1995 [PubMed 7665173]). It has been demonstrated that a Drosophila homeobox-containing gene called ft.tinman ft. is expressed in the developing dorsal vessel and in the equivalent of the vertebrate heart. Mutations in tinman result in loss of heart formation in the embryo, suggesting that tinman is essential for Drosophila heart formation. Furthermore, abundant expression of Csx, the presumptive mouse homolog of tinman, is observed only in the heart from the time of cardiac differentiation. CSX, the human homolog of murine Csx, has a homeodomain sequence identical to that of Csx and is expressed only in the heart, again suggesting that CSX plays an important role in human heart formation.
|PBS with no preservative; pH 7.4|
|CHNG5, CSX, CSX1, HLHS2, NKX2.5, NKX2E, NKX4-1, VSD3, NK2 transcription factor related, locus 5, cardiac-specific homeobox 1, homeobox protein CSX, homeobox protein NK-2 homolog E, homeobox protein Nkx-2.5, tinman paralog|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Immunoprecipitation, Western Blot|
|NKX2-5 (NP_004378, 1 a.a. ∽ 130 a.a) full length recombit protein with GST tag. MW of the GST tag alone is 26 KDa.|
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