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NLRX1 Rabbit anti-Equine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523496

Catalog No. PIPA523496


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Description

Description

NLR family member X1 (NLRX1) belongs to the NLRP family and contains four LRR (leucine-rich) repeats and one NATCH domain. NLRX1 localizes to the mitochondrial outer membrane and interacts through the mitochondrial antiviral signalling adaptor MAVS during viral infection. Expression of NLRX1 results in the potent inhibition of RLH- and MAVS-mediated interferon-beta promoter activity and in the disruption of virus-induced RLH-MAVS interactions. It is also reported that NLRX1 synergistically potentiated ROS production induced by tumour necrosis factor alpha, Shigella infection and double-stranded RNA, resulting in amplified NF-kappaB-dependent and JUN amino-terminal kinases-dependent signalling, thus contributing to the link between ROS generation at the mitochondria and innate immune responses.
Specifications

Specifications

NLRX1
Polyclonal
Unconjugated
NLRX1
Liquid
NLRX1
Portion of amino acid 580-630 of human NLRX1
Protein A
RUO
Antibody
Polyclonal
Equine, Human, Mouse, Non-human primate, Rat
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q86UT6, Q3TL44, Q5FVQ8
CLR11.3, DLNB26, NOD26, NOD5, NOD9, NLR family, X1, NOD-like receptor X1, caterpiller protein 11.3, nucleotide-binding oligomerization domain protein 26, nucleotide-binding oligomerization domain protein 5, nucleotide-binding oligomerization domain protein 9, nucleotide-binding oligomerization domain, leucine rich repeat containing X1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100071383, 270151, 315599, 79671
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