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NMDAR2A Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA34664

Catalog No. PA34664


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Description

Description

This antibody is specific for the ~180 kDa NR2A subunit of the NMDA Receptor. There is no reactivity towards the NR2B and NR2C subunits. Immunolabeling is blocked by preadsorption of antibody with the fusion protein used to generate the antibody.

The NMDA Receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer€™s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of th NMDAR2 (NR2 A-D) subunits.
Specifications

Specifications

NMDAR2A
Polyclonal
whole serum with no preservative
Q12879, P35436, Q00959
NMDAR2A, NMDAR
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
Unconjugated
GRIN2A
Liquid
GRIN2A
Fusion protein from the C-terminal region of the NR2A subunit of rat GRIN2A
50 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
14811, 24409, 2903
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