Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

NMDAR2B Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA34665

Catalog No. PA34665


Add to cart

Description

Description

This antibody is specific for the ~180 kDa NR2B subunit of the NMDA Receptor. There is no reactivity towards the NR2A and NR2C subunits. Immunolabeling is blocked by preadsorption of antibody with the fusion protein used to generate the antibody.

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal domit 6-related mental retardation.
Specifications

Specifications

NMDAR2B
Polyclonal
whole serum with no preservative
Q13224, Q01097, Q00960
NMDAR2B, NMDAR
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
Unconjugated
GRIN2B
Liquid
GRIN2B
Fusion protein from the C-terminal region of the NR2B subunit of rat GRIN2B
50 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
14812, 24410, 2904
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit