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nNOS/NOS Type 1 Mouse anti-Rat, Unlabeled, Clone: 52, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611852

Catalog No. BDB611852


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Description

Description

Nitric oxide synthase (NOS) is a cell-type specific enzyme which catalyzes the synthesis of nitric oxide (NO). NO is a short-lived radical which transmits cellular signals involved in vasorelaxation, neurotransmission, and cytotoxicity. In neurons and endothelial cells, constitutive NOS (cNOS) is activated by agonists that increase intracellular Ca2+concentrations and enhance calmodulin binding. Neuronal NOS (nNOS or bNOS) and endothelial NOS (eNOS) have recognition sites for NADPH, FAD, FMN, and calmodulin and are regulated in a similar manner. However, both have been shown to be distinct gene products of about 155kDa and 140kDa, respectively, and the human forms show 52% amino acid identity to each other. nNOS and the 130kDa inducible macrophage NOS (iNOS) share 51% amino acid homology. nNOS (neuronal NOS) is found in the cytoplasm of cell types such as neurons, skeletal muscle fibers, and lung epithelium. It is slightly larger than the other isoforms due to an N-terminal extension containing a PDZ domain through which it binds PSD-95 (post-synaptic density protein) and localizes to the cell membrane of synapses.

Host Species: Mouse
Clone: 52
Isotype: IgG1
Species Reactivity [for Features Main]: Rat
Immunogen: Rat nNOS/NOS Type I aa. 144-262

Western Blotting

Specifications

Specifications

nNOS/NOS Type 1
52
Unconjugated
Affinity Purified
Rat nNOS/NOS Type I aa. 144-262
50μg
Cell Biology
Primary
Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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