nNOS Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14121
PA1-4121 detects neuronal Nitric Oxide Synthase in human samples. PA1-4121 has been successfully used in Western blot procedures. The PA1-4121 immunogen is a synthetic peptide corresponding to residues P(19) R K G P P L P N G D T E C(31) of nNOS.Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains. eNOS and bNOS share ~50% sequence homology, and their activity depends on binding to the calcium/calmodulin complex. Both constitutive isoforms respond immediately to increased levels of calcium to produce low levels of NO over a short period of time. bNOS has been found in neurons, peripheral nerve cells, macula densa & pancreatic islet cells.
|Synthetic peptide corresponding to residues P(19) R K G P P L P N G D T E C(31) of nNOS.|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|Neuronal Nitric Oxide Synthase, NOS Type 1, Brain NOS, bNOS1|
|-20° C, Avoid Freeze/Thaw Cycles|
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