OPRL1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA3029
IHC (P) analysis shows positive staining of NOP in human enteric ganglion. WB analysis shows NOP in glycoprotein-enriched fractions from mock transfected or NOP overexpressing 293 cells. While NOP has a theoretical MW of ~ 41kD, the observed band in a WB runs at ~72kD due to enrichment of the glycosylated receptor.The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. The nociceptin receptor is a G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
|whole serum with 0.05% sodium azide|
|NOP, Nociceptin Receptor, Opiate Receptor-Like 1, NOPR, OPPRL1, Orphanin FQ Receptor, Kappa3-Related Opioid Receptor, Kappa-Type 3 Opioid Receptor, KOR-3, OOR, ORL1, LC132 Receptor-Like, NOCIR|
|Immunohistochemistry (Paraffin), Western Blot|
|KLH conjugated Cys-VRSIAKDVALACKTSETVPRPA|
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