Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

OPRL1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA3029

Catalog No. PIPA3029


Add to cart

Description

Description

IHC (P) analysis shows positive staining of NOP in human enteric ganglion. WB analysis shows NOP in glycoprotein-enriched fractions from mock transfected or NOP overexpressing 293 cells. While NOP has a theoretical MW of ~ 41kD, the observed band in a WB runs at ~72kD due to enrichment of the glycosylated receptor.

The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. The nociceptin receptor is a G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
Specifications

Specifications

OPRL1
Polyclonal
whole serum with 0.05% sodium azide
P41146
NOP, Nociceptin Receptor, Opiate Receptor-Like 1, NOPR, OPPRL1, Orphanin FQ Receptor, Kappa3-Related Opioid Receptor, Kappa-Type 3 Opioid Receptor, KOR-3, OOR, ORL1, LC132 Receptor-Like, NOCIR
Rabbit
IgG
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
OPRL1
Liquid
OPRL1
KLH conjugated Cys-VRSIAKDVALACKTSETVPRPA
100 μL
-20°C
Primary
4987
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit