NOD3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521016
A suggested positive control is NIH-3T3 cell lysate. PA5-21016 can be used with blocking peptide PEP-1130.NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predomitly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-βB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
|An 18 amino acid peptide near the center of human NOD3.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|CLR16.2, NOD3; CARD15-like protein; NOD-like receptor C3; caterpiller 16.2; caterpiller protein 16.2; nucleotide-binding oligomerization domain protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3; protein NLRC3|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|197358, 268857, 287070|
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