Nogo-A Mouse anti-Rat, Unlabeled, Clone: 17, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 612238
During neural development, many axons must travel long distances before reaching their dendritic targets and establishing synapses. After injury, these axonal connections can only regenerate in the peripheral nervous system, but not in the central nervous system (CNS). This difference in axon regeneration is thought to involve various inhibitory molecules found in the myelin of axons in the CNS. Nogo was identified in assays that examined fractions from myelin extracts for the antigen of monoclonal antibody IN-1, an antibody that allows modest
axon regeneration after spinal cord injury. Nogo is expressed as three different proteins, Nogo-A, -B, and -C, which are members of the Reticulon family of ER anchoring proteins. Nogo A is the full length protein, while Nogo-B contains 172 amino acids of the N-terminus and 188 amino acids of the C-terminus of Nogo-A, and Nogo-C contains only the 188 amino acid C-terminus of Nogo-A. These splice variants are all found in optic nerve, spinal cord, and cerebral cortex, but differ in expression in other neuronal and non-neuronal tissues. Thus, Nogo-A is a myelin-associated protein that may have roles in the ER, as well as during axon regeneration.
Immunofluorescence, Western Blotting
|Rat Nogo-A aa. 424-627|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok