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NDP Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520722

Catalog No. PIPA520722


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Description

Description

A suggested positive control is Jurkat cell lysate. PA5-20722 can be used with blocking peptide PEP-0836.

Norrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/beta-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina; transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/beta-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.
Specifications

Specifications

NDP
Polyclonal
Unconjugated
NDP
Liquid
NDP
An 18 amino acid peptide from near the amino terminus of human Norrin.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q00604
EVR2, FEVR, ND; X-linked exudative vitreoretinopathy 2 protein; norrie disease protein; norrin
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
4693
Documents
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