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NOTCH2 Rat anti-Human, Mouse, Clone: 605724, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA524274

Catalog No. PIMA524274


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Description

Description

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. To date, four Notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The Notch genes are expressed in a variety of tissues in both the embryonic and adult organism, suggesting that the genes are involved in multiple signaling pathways. The Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged2 and Delta. Jagged can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions.
Specifications

Specifications

NOTCH2
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q04721, O35516
Neurogenic locus notch homolog protein 2, Notch 2, hN2, Notch 2 extracellular truncation, Notch 2 intracellular domain, NOTCH2
Rat
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
18129, 4853
Flow Cytometry, Immunocytochemistry, Immunofluorescence
605724
Unconjugated
NOTCH2
Lyophilized
NOTCH2
CHO-derived recombit mouse Notch-2 Leu26-Val528 (predicted)
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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