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NOTCH2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527458

Catalog No. PIPA527458


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Description

Description

PA5-27458 targets Notch 2 in WB applications and shows reactivity with Human and mouse samples. The PA5-27458 immunogen is recombit fragment corresponding to a region within amino acids 1669 and 1855 of Human Notch 2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.
Specifications

Specifications

NOTCH2
Polyclonal
Unconjugated
NOTCH2
Liquid
NOTCH2
Recombit fragment corresponding to a region within amino acids 1669 and 1855 of Human Notch 2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
ChIP assay, Western Blot
1 mg/mL
PBS with 40% glycerol and 0.01% thimerosal; pH 7
Q04721, O35516
AGS2, HJCYS, hN2, Notch homolog 2, neurogenic locus notch homolog protein 2
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
18129, 4853
Documents
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