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NOTCH3 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA528082

Catalog No. PIPA528082


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Description

Description

PA5-28082 targets Notch 3 in WB applications and shows reactivity with Human samples. The PA5-28082 immunogen is synthetic peptide corresponding to a region within amino acids 2256 and 2321 of Human Notch 3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal domit arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Specifications

Specifications

NOTCH3
Polyclonal
Unconjugated
NOTCH3
Liquid
NOTCH3
Synthetic peptide corresponding to a region within amino acids 2256 and 2321 of Human Notch 3
Protein A
RUO
Antibody
Polyclonal
Human
Western Blot
5.26 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Q9UM47
CADASIL, CASIL, Notch homolog 3, neurogenic locus notch homolog protein 3
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
4854
Documents
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