NOTCH3 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528082
PA5-28082 targets Notch 3 in WB applications and shows reactivity with Human samples. The PA5-28082 immunogen is synthetic peptide corresponding to a region within amino acids 2256 and 2321 of Human Notch 3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal domit arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
|Synthetic peptide corresponding to a region within amino acids 2256 and 2321 of Human Notch 3|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|CADASIL, CASIL, Notch homolog 3, neurogenic locus notch homolog protein 3|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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