NOTCH1 Rabbit anti-Bovine, Canine, Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523181
DescriptionThe Notch protein family contains a group of highly conserved single-pass, ligand-activated transmembrane receptors involved in cell fate selection and maintece of progenitors during development. These proteins also function as transcription factors. Notch proteins mainly consist of an extra cellular domain containing tandem EGF-repeats and three lin-12/Notch repeats, a transmembrane domain and an intracellular domain containing six cdc1/SW16/ankyrin repeats, RAM motif, nuclear localization signals and a C-terminal OPA/PEST region. NOTCH1, a mammalian homolog of Drosophila Notch, is an important member of this family. Physiological functions influenced by NOTCH proteins include maintece of hematopoietic stem cells, T-cell development, neuronal function and development, angiogenesis, arterial and ventricular development and differentiation, cardiac valve homeostasis, cell lineage specification of endocrine and exocrine pancreas, development of actin cytoskeleton and bone regeneration. Abnormal Notch signaling has been associated with several diseases including cancer, leukemia, melanoma, T-ALL, CADASIL, Multiple Sclerosis, Tetralogy of Fallot and Alagille Syndrome.
|Synthetic peptide (1755 VLLSRKRRRQHGQC 1767) of Notch1/Notch1 cleaved protein.|
|Bovine, Canine, Human, Mouse, Rat|
|PBS with 0.2% gelatin and 0.05% sodium azide|
|P46531, Q01705, Q07008|
|TAN1, hN1, Notch homolog 1, translocation-associated, neurogenic locus notch homolog protein 1, translocation-associated notch protein TAN-1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|18128, 25496, 480676, 4851, 767866|
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