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NOTCH1 Rabbit anti-Bovine, Canine, Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523181

Catalog No. PIPA523181


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Description

Description

The Notch protein family contains a group of highly conserved single-pass, ligand-activated transmembrane receptors involved in cell fate selection and maintece of progenitors during development. These proteins also function as transcription factors. Notch proteins mainly consist of an extra cellular domain containing tandem EGF-repeats and three lin-12/Notch repeats, a transmembrane domain and an intracellular domain containing six cdc1/SW16/ankyrin repeats, RAM motif, nuclear localization signals and a C-terminal OPA/PEST region. NOTCH1, a mammalian homolog of Drosophila Notch, is an important member of this family. Physiological functions influenced by NOTCH proteins include maintece of hematopoietic stem cells, T-cell development, neuronal function and development, angiogenesis, arterial and ventricular development and differentiation, cardiac valve homeostasis, cell lineage specification of endocrine and exocrine pancreas, development of actin cytoskeleton and bone regeneration. Abnormal Notch signaling has been associated with several diseases including cancer, leukemia, melanoma, T-ALL, CADASIL, Multiple Sclerosis, Tetralogy of Fallot and Alagille Syndrome.
Specifications

Specifications

NOTCH1
Polyclonal
Unconjugated
NOTCH1
Liquid
NOTCH1
Synthetic peptide (1755 VLLSRKRRRQHGQC 1767) of Notch1/Notch1 cleaved protein.
Protein G
RUO
Antibody
Polyclonal
Bovine, Canine, Human, Mouse, Rat
Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
P46531, Q01705, Q07008
TAN1, hN1, Notch homolog 1, translocation-associated, neurogenic locus notch homolog protein 1, translocation-associated notch protein TAN-1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
18128, 25496, 480676, 4851, 767866
Documents
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