NOTCH3 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA513203
This antibody is predicted to react with human based on sequence homology.NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal domit arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
|KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3|
|Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.09% sodium azide|
|Neurogenic locus notch homolog protein 3; Notch 3;|
|-20° C, Avoid Freeze/Thaw Cycles|
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