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NOTCH3 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522797

Catalog No. PIPA522797


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Description

Description

NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are associated with cerebral autosomal domit arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (swissprot).
Specifications

Specifications

NOTCH3
Polyclonal
Unconjugated
NOTCH3
Liquid
NOTCH3
Synthetic peptide representing the C terminal region of the human NOTCH homolog 3 (NOTCH3) protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
ELISA, Immunohistochemistry (Frozen), Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9UM47
CADASIL, CASIL, Notch homolog 3, neurogenic locus notch homolog protein 3
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
4854
Documents
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