NOTCH3 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA522797
DescriptionNOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are associated with cerebral autosomal domit arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (swissprot).
|Synthetic peptide representing the C terminal region of the human NOTCH homolog 3 (NOTCH3) protein.|
|Antigen affinity chromatography|
|ELISA, Immunohistochemistry (Frozen), Western Blot|
|PBS with 0.02% sodium azide|
|CADASIL, CASIL, Notch homolog 3, neurogenic locus notch homolog protein 3|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok