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NR0B2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA524551

Catalog No. PIPA524551


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Description

Description

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Specifications

Specifications

NR0B2
Polyclonal
PBS with 0.09% sodium azide
Q15466
SHP, SHP1, nuclear receptor SHP, nuclear receptor subfamily group B member 2, orphan nuclear receptor SHP, small heterodimer partner
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8431
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
NR0B2
Liquid
NR0B2
KLH conjugated synthetic peptide between 56-83 amino acids from the central region of human NR0B2
Protein A, Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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