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NUP53 Rabbit anti-Yeast, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA15852

Catalog No. 01-675-390


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Description

Description

PA1-5852 detects Nup53p in yeast samples. PA1-5852 has been successfully used in Western blot and immunofluorescence procedures. The PA1-5852 immunogen is purified recombit Nup53p.

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predomitly with GTP in the nucleus, with GDP in the cytoplasm). NUP53 may play an important role in cell cycle regulation by inhibiting PSE1 transport functions during mitosis and sequestration of MAD1-MAD2 in a cell cycle-dependent manner. It also seems to play an important role in de novo NPC assembly by associating with nuclear membranes and driving their proliferation.
Specifications

Specifications

NUP53
Polyclonal
whole serum with 0.1% sodium azide
Q03790
YMR153W
Rabbit
IgG
RUO
Antibody
Polyclonal
Yeast
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
NUP53
Liquid
NUP53
Purified recombit Nup53p.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
855184
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