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NUMB Rabbit anti-Bovine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523486

Catalog No. PIPA523486


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Description

Description

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
Specifications

Specifications

NUMB
Polyclonal
Unconjugated
NUMB
Liquid
NUMB
Synthetic peptide (12 KDVYVPEASRPHQWQTDEE 30) of NUMB protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Human, Mouse, Non-human primate, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
P49757, Q9QZS3, Q2LC84
C14orf41, S171, c14_5527, h-Numb, protein numb homolog
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
18222, 29419, 512187, 8650
Documents
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