NUMB Rabbit anti-Bovine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523486
DescriptionProtein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
|Synthetic peptide (12 KDVYVPEASRPHQWQTDEE 30) of NUMB protein.|
|Antigen affinity chromatography|
|Bovine, Human, Mouse, Non-human primate, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|P49757, Q9QZS3, Q2LC84|
|C14orf41, S171, c14_5527, h-Numb, protein numb homolog|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|18222, 29419, 512187, 8650|
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