NUP98 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527763
PA5-27763 targets NUP98 in WB applications and shows reactivity with Human samples. The PA5-27763 immunogen is recombit fragment corresponding to a region within amino acids 121 and 578 of Human NUP98. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
|Recombit fragment corresponding to a region within amino acids 121 and 578 of Human NUP98|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|ADIR2, NUP196, NUP96, GLFG-repeat containing nucleoporin, Nup98-Nup96, nuclear pore complex protein Nup98-Nup96|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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