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Occludin, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA139441

Catalog No. PA139441

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Occludin is a 65kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. This phosphorylation is thought to be involved in regulating both the localization and the function of Occludin. Polyunsaturated fatty acids are known to up-regulate Occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue, Occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution.

Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is lung tissue.
Specifications

Specifications

Occludin
Polyclonal
TBS with 1% BSA and <0.1% sodium azide; pH 7.6
Q16625
OCLN
Synthetic peptide corresponding to C-terminus of human occludin
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
Unconjugated
OCLN
Liquid
Rabbit
IgG
7mL
4° C, do not freeze
Primary
100506658
Documents
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