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Occludin Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520755

Catalog No. PIPA520755


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Description

Description

A suggested positive control is human liver tissue lysate. PA5-20755 can be used with blocking peptide PEP-0869.

Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.
Specifications

Specifications

Occludin
Polyclonal
Unconjugated
OCLN
Liquid
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
100506658, 18260, 83497
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q16625, Q61146, Q6P6T5
OCLN
A 15 amino acid peptide from near the carboxy terminus of human OCLN.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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