OCT1 (POU2F1) Rabbit anti-Canine, Equine, Human, Non-human primate, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523392
DescriptionOCT-1, Octamer binding transcription factor 1 binds to an octamer motif (5 ft.-ATTTGCAT-3 ft.) and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes for immunoglobulins. POU domain proteins contain a bipartite DNA-binding domain, which is divided by a flexible linker that enables them to adopt various monomer configurations on DNA. The versatility of POU protein operation is conferred at the dimerization level. POU dimer from the OCT-1 gene formed on the palindromic OCT factor recognition element, or PORE, could recruit the transcriptional coactivator OBF1. This octamer sequence within immunoglobulin promoters are sufficient for lymphoid-specific promoter activity in lymphoid cells. Oct-1 regulates the expansion and/or maintece of mature B cells. In its absence mature B-cell pull is strongly reduced.
|Synthetic peptide (4 CSDYVLDSR 12) of OCTL1/OCT-1 protein.|
|Canine, Equine, Human, Non-human Primate|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|OCT1, OTF1, oct-1B, NF-A1, OTF-1, Octamer-binding transcription factor-1, POU domain, class 2, transcription factor 1, oct-1, octamer-binding protein 1, octamer-binding transcription factor 1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|100051363, 490360, 5451|
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