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OLIG1/OLIG2/OLIG3 Mouse anti-Human, Clone: 257224, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523805

Catalog No. PIMA523805


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Description

Description

In direct ELISAs, this antibody shows approximately 20% cross-reactivity with recombit human (rh) Olig2 and 50-100% cross-reactivity with rhOlig3. Reconstitute at 0.5 mg/mL in sterile PBS.

Olig1 promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube. Olig2 is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
Specifications

Specifications

OLIG1/OLIG2/OLIG3
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q13516, Q7RTU3, Q8TAK6
olig1, olig2, olig3, Oligodendrocyte transcription factor 2 antibody, Oligo2 antibody, Basic helix-loop-helix protein class B 1 antibody, Protein kinase C-binding protein, Oligodendrocyte transcription factor 1, Oligo1, Class B basic helix-loop-helix protein 6, bHLHb6, Class E basic helix-loop-helix protein 21, bHLHe21, BHLHB6, BHLHE21Oligodendrocyte transcription factor 3, Class B basic helix-loop-helix protein 7, bHLHb7, Class E basic helix-loop-helix protein 20, bHLHe20, BHLHB7, BHLHE20
Mouse
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
10215, 116448, 167826
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)
257224
Unconjugated
OLIG3
Lyophilized
OLIG1, OLIG2, OLIG3
E. coli-derived recombit human Olig1 (aa 1-272)
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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