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Oligomer A11 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen AHB0052

Catalog No. AHB0052


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Description

Description

This antibody recognizes amino acid sequence-independent oligomers of proteins or peptides. A11 does not recognize monomers or mature fibers of proteins or peptides. A11 reacts with soluble AB40 oligomers and does not react with soluble low molecular weight AB40 or AB40 fibrils. A11 recognizes oligomeric species of several other amyloidogenic polypeptides including AB42, human insulin, prion, polyglutamine, lysozyme, alpha-synuclein and yeast prion Sup35. Oligomeric AB42 is recommended as a positive control, monomeric and fibrillar AB42 as negative controls.

Many degenerative diseases are known to be related to the accumulation of misfolded proteins called, amyloid fibrils. Soluble amyloid oligomers are considered as the principal pathogenic species which play an important role in the formation of amyloid fibrils; therefore, oligomers are involved in the pathogenesis of the many neurodegenerative diseases. This anti-oligomer antibody provides a facile means of assessing the significance of oligomers in disease pathogenesis.

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Specifications

Specifications

Oligomer A11
Polyclonal
PBS with 0.1% sodium azide; pH 7.4
P01308, P01325, P01322
INS, Ins1
Synthetic molecular mimic of soluble oligomers.
Purified
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Dot Blot, ELISA, Immunohistochemistry, Neutralization
Unconjugated
INS
Liquid
Rabbit
IgG
50 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
16333, 24505, 3630
SDS
Documents
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