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MilliporeSigma™ anti-Opioidµ Receptor (384-398), Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC165L100UL

Catalog No. PC165L100UL


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Description

Description

Specifically detects Opioidµ Receptor (384-398) Clone: in Rat samples, and it is validated for Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation, Immuno Blotting

Opioid peptides are endogenous neuromodulators, which have been identified from brain, and play a major role in the nociceptive pathway by interacting with several membrane receptors, defined asµ,,delta;, and,kappa;. These peptides are derived from the cleavage of precursor proteins to produce theβ-endorphin, enkephalin, and dynorphin peptides. Leu-enkephalin, Met-enkephalin, andβ-endorphin all bind theµ and,delta; receptors with high affinity, whileβ-endorphin also exhibits low affinity,kappa; binding. Dynorphin A and dynorphin B both bind the,kappa; receptor with high affinity. In addition to these endogenous peptides, a number of exogenous nonpeptide molecules known as alkaloids or opiates also interact with the receptors to mediate a number of biological events which include the modulation of pain, analgesia, behavior, locomotor activity, and neuroendocrine physiology. Although the,delta; opioid receptor subtype was the first subtype identified, all three receptor classes are G protein-coupled receptors which have been shown to inhibit adenylate cyclase, decrease the conductance of voltage-gated Ca2+ channels, or activate K+ channel current.
Specifications

Specifications

Opioidμ Receptor (384-398)
Unconjugated
Undiluted Serum
a synthetic peptide corresponding to amino acids 384-398 of rat opioid μ receptor
100μL
−20°C
Polyclonal
Rat
Immuno Blotting, Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation
Undiluted serum.
Rabbit
IgG
RUO
Primary
Recognizes the ∽44-45kDa opiodμ receptor in caudate putamen and the dorsal horn of the spinal cord.
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