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ORAI1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520402

Catalog No. PIPA520402


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Description

Description

Despite the predicted molecular weight, ORAI1 often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is human ovary tissue lysate. PA5-20402 can be used with blocking peptide PEP-0519.

Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.
Specifications

Specifications

ORAI1
Polyclonal
Unconjugated
ORAI1
Liquid
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
109305, 304496, 84876
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q96D31, Q8BWG9, Q5M848
ORAI1
A 16 amino acid peptide from near the carboxy terminus of human ORAI1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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