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p130 Mouse anti-Human, Mouse, Rat, Clone: KAB40, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112364

Catalog No. 01-674-288


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Description

Description

This antibody recognizes both the phosphorylated or unphosphorylated forms of p130 at a MW of 130kDa. It is suitable for use in Western blot with His-tagged or GST-tagged proteins.

Two retinoblastoma related proteins, p107 and pRb2 / p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the ""pocket domain."" Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.
Specifications

Specifications

p130
Monoclonal
Unconjugated
RBL2
Liquid
RBL2
GST fusion protein to the N terminus of p130.
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Western Blot
KAB40
PBS with 0.08% sodium azide
Q08999, Q64700, O55081
Retinoblastoma related protein
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
19651, 5934, 81758
Documents
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